WebFeb 18, 2024 · Abstract and Figures. This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains ... WebApr 18, 2016 · Indeed, aggregation prone regions enriched in aliphatic amino acids appear to be important in protein-protein interactions 40,41. Interestingly, positively charged residues (including Arg and Lys ...
Aggregation Prone Regions (APRs) VIB Switch Laboratory
WebJan 9, 2024 · A novel ANO5 splicing variant in a LGMD2L patient leads to production of a truncated aggregation-prone Ano5 peptide. Jing Xu, Jing Xu. Division of Cardiovascular Medicine, Department of Cardiac Surgery, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA ... WebMay 3, 2024 · Intrinsically aggregation-prone proteins form amyloid-like aggregates and contribute to tissue aging in Caenorhabditis elegans. Elife. 2024 May 3;8:e43059. doi: … larry koss altamont il
Design of therapeutic proteins with enhanced stability PNAS
WebApr 14, 2024 · Protein aggregation is a hallmark of multiple human pathologies. Autophagy selectively degrades protein aggregates via aggrephagy. How selectivity is achieved has been elusive. Here, we identify the chaperonin subunit CCT2 as an autophagy receptor regulating the clearance of aggregation-prone proteins in the cell and the mouse brain. WebDec 17, 2024 · Most of the aggregation-prone regions are hidden within the 3D structures and, therefore, they cannot realize their potential to aggregate. Thus, the … WebDec 17, 2024 · Most of the aggregation-prone regions are hidden within the 3D structures and, therefore, they cannot realize their potential to aggregate. Thus, the most realistic census of the aggregation prone regions requires crossing aggregation prediction with information about the location of the natively unfolded regions. This allows us to detect so ... larry linkous