2024 Cholesteryl pullulan

Cholesteryl pullulan

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WebAbstract. In this study, a novel nanoparticulate drug delivery platform with inherent targeting ability to hepatic carcinoma cells and reduction-triggered drug release … WebOVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1 …

(PDF) Mucosal vaccines (PP-049) sapta mulyatno - Academia.edu

WebMay 2, 2024 · Common side effects of cholestyramine may include: mild constipation, diarrhea; stomach pain, nausea, loss of appetite; bloating or gas; irritation of your … WebOct 26, 2016 · Pullulan is a natural and chemically neutral homopolysaccharide consisting of α-1, 6-linked maltotriose units (maltotriose is three glucose molecules linked with α-1, 4 glycosidic … structure therapeutics prospectus

Eiichi Sato

WebNov 1, 2006 · We previously reported that cholesteryl pullulan (CHP) deriva-tives were effective carriers drug delivery systems in targeting cancer cells. We have now synthesized folic acid-conjugated CHP... WebMar 22, 2024 · We have been developing the cholesteryl pullulan (CHP)-antigen protein nanoparticle as a cancer vaccine for esophageal cancer [ 13, 14 ]. A CHP nanoparticle that contains a tumor antigen is a new type of cancer vaccine with a novel antigen delivery system for both the MHC class I and class II pathways. WebNov 19, 2015 · A self-assembled nanogel is constructed from light-sensitive cholesteryl pullulan (Ls-CHP) by using photo-labile ortho-nitrobenzyl (o-NB) units. The nanogel-based film is obtained by evaporation of an Ls-CHP nanogel solution. Exposure of the resulting nanogel-based film to light with a mask resulted in a pat structure therapeutics logo

Safety and antibody immune response of CHP-NY-ESO-1

Mucosal vaccines: wisdom from now and then - PMC - National …

WebDec 6, 2012 · Self-assembled protein-loaded pH-sensitive cholesteryl pullulan-based nanogels were developed to retain the encapsulated protein at the physiological … WebJan 2, 2014 · The cholesteryl pullulan, with an average degree of substitution of 5.4 per 100 glucose units, was prepared by reacting pullulan with cholesterol succinate according to a procedure already reported (Yang et al., 2010), and the structure of CHSP is shown in Fig. 1. Download : Download full-size image; Fig. 1. The synthesis route of Bio-CHSP. structure thinkingWebJan 8, 2024 · Fujioka-Kobayashi et al. studied the combination of FGF-18 with the bone morphogenic protein (BMP)-2 and found it was sufficient at showing significant bone regeneration potential in crosslinked acrylol cholestrol modified pullulan nanogels. These factors were combined with stimulated thick trabecular bone formation . Charoenlarp et … structure theory of finite conformal algebras

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Cholesteryl pullulan

Polysaccharide-based nanogels for biomedical applications: A ...

WebSummary. Cholestyramine (Questran, Questran Light) is a medication prescribed to reduce cholesterol level in the blood, relieve itching of liver disease, and to treat overdoses of … WebJun 20, 2010 · A nanometre-sized hydrogel consisting of a cationic type of cholesteryl group bearing pullulan has now been used as an intranasal vaccine-delivery system.

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WebOct 5, 2013 · Background: Cholesteryl pullulan (CHP) is a novel antigen delivery system for cancer vaccines. This study evaluated the safety, immune responses and clinical … WebDec 25, 2024 · Pullulan has been progressively defined as base-producing material of gene and drug nanocarriers. The most popular feature of these nanocarriers is the utilization of hydrophobic derivatives of pullulan, like cholesteryl-pullulan since this produces an amphiphilic pullulan derivative with the ability to form nanoparticles by self-aggregation.

WebAn object is to provide a new cosmetic composition that can prevent or reduce skin “photoaging” caused by blue light. As a solution, a cosmetic composition is provided, which is characterized in that it contains: (a) one or more types of alkyl phosphate esters selected from alkyl phosphate esters having alkyl groups with 12 to 36 carbon atoms; (b) one or … WebExpert opinion: The most advanced models of nanogel-based vaccines comprise candidates against cancer, based on cholesteryl pullulan nanogels evaluated in clinical trials with promising findings; as well as some vaccines against respiratory pathogens tested in …

Web暨南大学,数字图书馆. 开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebOct 29, 2009 · However, there are no standard therapies established for recurrent esophageal cancer. NY-ESO-1 antigen is expressed in 33% of patients. NY-ESO-1 protein is applicable without limitation by HLA types, and injected as a complex with cholesteryl pullulan (CHP), forming nano-particles (IMF-001), it can activate both CD4+ and CD8+ …

WebMar 25, 2011 · Cholesteryl group-bearing pullulan complexed with the truncated HER-2 protein, delivered a HER-2 oncoprotein containing an epitope peptide to the major histocompatibility complex class I pathway, and was able to induce CD8+ cytotoxic T lymphocytes against HER-2+ tumors and caused complete rejection of tumors.

WebJan 1, 2014 · Intracellular delivery of exogenous proteins is a field of bioscience that has grown rapidly in recent years, driven by the potential clinical applications. We developed a protein nanocarrier composed of amphiphilic polysaccharide nanogels formed by self-assembly of ethylenediamine- and cholesteryl group-bearing pullulan (CHP-NH 2). The … structure thing membrane suffixWebAug 26, 2024 · Cholesteryl-group-bearing pullulan (CHP) forms physically cross-linked nanogels through self-assembly of associating polymers in water (47, 48). structure timers eve onlineWebNov 1, 2006 · We previously reported that cholesteryl pullulan (CHP) deriva-tives were effective carriers drug delivery systems in targeting cancer cells. We have now … structure theory sociologyWebHere, we synthesized cholesteryl-modified aminated pullulan polymers (CHPNs) with different amounts of cholesterol succinate (CHS). We characterized the three hydrophobically modified polymers (CHPN 1, … structure through which guttation takes placeWebDec 15, 2006 · HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan CHP-HER2 vaccine was safe and induced HER2-specific CD8(+) and/or CD4(+) T-cell immune responses. CHP-HER2 vaccine was safe and induced HER2-specific CD8(+) and/or … structure third conditionalWebAnother feature of cholesteryl-pullulan nanoparticles is that they can interact hydrophobically with oligomeric forms of beta-amyloid, exhibiting the ability to significantly reduce their toxicity, which stands out as a potential complementary strategy present in neurological disorders with the formation of soluble toxic aggregates, an example ... structure to smiles chemdrawWebApr 11, 2024 · The obtained cholesteryl-hyaluronic acid-drug compounds were rapidly shaped into compressed NG with a size of 50 nm with the help of ultrasonication [60]. The method of developing hydrophobic cholesterol-altered amino-pullulan (CHAP) compounds from pullulan that has been grafted with hydrophobic groups and ethylenediamine is … structure title group tn