WebA new controlled-release gastrointestinal therapeutic system (GITS) formulation of doxazosin was developed to enhance the pharmacokinetic profile, significantly reducing serum peak-to-trough ratios, thereby minimizing the need for titration. WebDec 21, 1987 · Nifedipine is an insoluble, shortacting calcium channel blocker that presents a difficult technical challenge for formulation in a constant 24-hour delivery dosage form. Once-a-day dosage forms have been developed based on the gastrointestinal therapeutic system (GITS) push-pull osmotic pump configuration in three strengths with different drug ...
Doxazosin Gastrointestinal Therapeutic System SpringerLink
WebFeb 15, 2005 · The new formulation, doxazosin gastrointestinal therapeutic system (GITS), is initiated at a therapeutic dose, simplifying dose titration. Based on its efficacy and pharmacokinetic and... WebJan 5, 2024 · Procardia XL and Nifedical XL are 2 example brand names for the GITS formulation, while Adalat CC and Nifediac CC are 2 example brand names for the CC … cld24 av
National Center for Biotechnology Information
WebThis article focuses on this issue with respect to nifedipine and the development of the gastrointestinal therapeutic system (GITS) formulation. Nifedipine GITS is regarded as the gold standard once-daily formulation of nifedipine and, as such, it is anticipated that alternative formulations will be therapeutically equivalent to nifedipine GITS. WebJul 1, 1997 · Patients who are taking the GITS formulation of nifedipine as a sole antihypertensive agent can safely be switched to the CC preparation without a clinically important sacrifice in blood pressure control or a major increase in adverse effects that might lead to drug discontinuation. WebNov 28, 2024 · Git is a distributed version control system, which means that a local clone of the project is a complete version control repository. These fully functional local … down syndrome hedgehog