Web8 apr. 2024 · Nonalcoholic fatty liver disease (NAFLD), obesity, and type 2 diabetes mellitus (T2DM) have highly related mechanisms. Ramulus Mori (Sangzhi) alkaloids (SZ-A) from Morus alba L. were approved in 2024 for the treatment of T2DM. In this study, we examined the therapeutic effects and mechanism of SZ-A on obesity and NAFLD in mice. Mice … WebResearch shows that patients with severe COVID-19 tend to have higher concentrations of pro-inflammatory cytokines (such as Tumour Necrosis Factor-α (TNF-α), Interleukin-1β …
MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation …
WebIn addition, loss of MMP-3 repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 and (C-X-C motif) ligand 1 (CXCL1). These findings suggest a contribution of MMP-3 during EIU, and its potential use as a therapeutic drug target in reducing ocular inflammation. Keywords: WebMacrophage inflammatory protein 1α (MIP-1α) is a monocyte-, neutrophil- and lymphocyte-derived CC chemokine family member with inflammatory and chemokinetic properties … p selectin mouse
MCP-1: Function, regulation, and involvement in disease
WebThe targeting of MCP-1 is a potential therapeutic approach in a series of human disorders that includes multiple sclerosis, obesity-associated inflammation, and cancer metastasis … WebThe expressions of proinflammatory cytokines (MCP-1, IL-1β, and TNF-α) were predominantly observed in the gastric mucosal layers of the stressed mice. Furthermore, stress remarkably elevated the gastric mucosal mRNA expression levels of MCP-1, … WebGenotypes of rs1024611 and rs4586 with minor alleles had a significantly higher circulating level of MCP1 ( P < 0.001). Meanwhile, a circulating level of MCP1 was significantly associated with increased COPD risk (OR for per quartile increment=1.35, 95% CI=1.21– 1.52, P < 0.001). Conclusion: Our study indicated that genetic polymorphisms of ... horse albumin