Web8 jul. 2024 · The NR4A nuclear orphan receptors, NR4A1-3, are transcription factors whose expression is rapidly induced following a variety of stimuli . Several roles have been suggested for NR4A nuclear orphan receptor family members within the myeloid lineage. WebNuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. NR4A1 is involved in cell cycle mediation, inflammation …

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WebDownload or read book The Role of NR4A Orphan Nuclear Receptors in Glucose Metabolism and Inflammation written by Liming Pei and published by . This book was … Web14 apr. 2024 · In acute myeloid leukemia, dihydroergotamine (DHE)—a drug activator of NR4A nuclear receptors—represses the expression of a selected group of SE-associated leukemic oncogenes including MYC . DHE inhibits MYC SE functional activity by eliminating eRNA transcription and enhancer–promoter looping and suppresses tumor growth both … bongo wedge shoes

NR4A1 nuclear receptor subfamily 4 group A member 1 [ (human)]

Web15 jul. 2016 · A recent metabolomics study identified unsaturated fatty acids, including arachidonic acid and docosahexaenoic acid (DHA), that interact with the ligand-binding domain (LBD) of a related orphan receptor, Nur77/NR4A1. However, the binding location and whether these ligands bind other NR4A receptors were not defined. Web1 dec. 2008 · NR4A Receptors Inhibit the Differentiation of 3T3 Preadipocytes Stable cell lines were generated by retroviral transduction as described in Materials and Methods. 3T3-L1 cells were induced to differentiate with DMI alone (top row) or DMI and GW7845 (third row). 3T3-L1 cells expressing both PPARγ and NR4A receptors were differentiated with … Web11 apr. 2024 · The authors used mass spectrometry to identify proteins that interacted with biotinylated LPS in these cells and found Nur77 as a top candidate. 1 Nur77 is a member of the orphan nuclear receptor 4A (NR4A) family of transcription factors that has been implicated in a variety of cellular processes ranging from metabolism to inflammation. 5 … bongo watch vintage chain mail band