Pim1 and p27
WebJul 31, 2002 · The p27 Kip1 protein is a cyclin-dependent kinase inhibitor that blocks cell division in response to antimitogenic cues. p27 expression is reduced in many human … WebOct 7, 2010 · PIM1 is a constitutively active serine/threonine kinase regulated by cytokines, growth factors and hormones. It has been implicated in the control of cell cycle progression and apoptosis and its overexpression has been associated with various kinds of lymphoid and hematopoietic malignancies.
Pim1 and p27
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WebOncogenic Pim-1 kinase is upregulated in multiple solid cancers, including human pancreatic ductal adenocarcinoma (PDAC), a highly lethal disease with few useful …
WebNational Center for Biotechnology Information WebJun 12, 2014 · PIM1 kinase is overexpressed in many tumor types including lymphomas and prostate cancer, where it is known to cooperate with the MYC oncogene in promoting tumorigenicity. PIM1 has emerged as an attractive target for drug discovery, but few PIM1 inhibitors have been tested in vitro or in vivo.
WebApr 29, 2024 · PIM kinases are constitutively active proto-oncogenic serine/threonine kinases that play a role in cell cycle progression, metabolism, inflammation and drug resistance. PIM kinases interact with and stabilize p53, … Web精品Skp2相关衰老信号通路的抗肿瘤机制.pdf
Web(B) p27, an inhibitor of cyclin-dependent kinases (CDK), is a key regulator of cell cycle progression. In a pathological condition, many oncogenic kinases phosphorylate p27 on …
WebRegulation of PIM-1 kinase activities. Structural analysis revealed that the PIM-1 protein contains a constitutively active kinase conformation that does not require to be phosphorylated for activation. 17 This means that the level of PIM-1 enzymatic activity in a cell is dependent on the absolute amount of protein present. Typically, both PIM-1 mRNA … southwood arenaWebTargetScans algorithm-based prediction demonstrated that CDKN1B (p27, Kip1), a cell cycle regulator, was a putative target of miR-24, and was confirmed by luciferase assay. The expression of p27 was decreased in TAC rat cardiac tissue (t = 2.896, P< 0.05). southwood armsWebCyclin-Dependent Kinase Inhibitor p27 PIM1 protein, human Proto-Oncogene Proteins c-pim-1 Proto-Oncogene Proteins p21(ras) ras Proteins Grant support CA109550/CA/NCI NIH HHS/United States R01 CA140424/CA/NCI NIH HHS/United States CA92077/CA/NCI NIH HHS/United States ... southwood army campWebMay 19, 2016 · Luciferase assays with the Pim1 3′-UTR found no decrease by miR-124a . microRNAs miR-33a (a known Pim1 target) 21 and miR-214 (a putative high-seed match to the Pim1 3′UTR), both targeted Pim1 . Although the effects of miR-33a were previously reported, this is the first report demonstrating that miR-214 can directly target the Pim1 … southwood art of livingWebFeb 4, 2024 · Decrease in proliferation is linked with an increased expression of the CDK inhibitors (P27 and/or P21). This inhibition of PIM1 decreases the cell viability. While, upregulation of the PIM1 with cDNA transfection rescues the inhibition of viability, migration, proliferation of OC cells and their cell-cycle phase 1 accumulation . This data ... southwood assisted livingWeb描述了降解剂‑抗体缀合物(DAC)，该降解剂‑抗体缀合物包含抗TM4SF1抗体及其抗原结合片段。所述的降解剂分子包含泛素E3连接 ... southwood arena woodstockWebJun 12, 2012 · My research projects focusing on: 1) roles of CKI molecules (p27, p57,14-3-3 σ) in tumorigenesis 2) COP9 signalosome signaling regulation, 3) investigating the impact of hypoxia and PIm1 kinase ... southwood arms huntsville tx